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From reference 253 with permission of Elsevier BV) (B) Increased drug concentrations in P-glycoprotein knockout mice ( 149)! And appellate tribunals have the duty to make an independent evaluation of the circumstances.
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NSAIDs cause a dose-dependent reduction in prostaglandin formation, which may result in a reduction in renal blood flow leading to renal insufficiency and an increase in blood pressure that are often accompanied by peripheral edema and weight gain.
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